PMF Scores Calculator

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Primary Myelofibrosis (PMF) prognostic scores calculator

Clinical Features

Age (y):

Gender: Male Female

Constitutional Symptoms: Yes No N/A

RBC transfusions need: Yes No N/A

Karnofsky <90%: Yes No N/A

HLA-mismatched unrelated donor: Yes No N/A

Additional Myeloid Mutations

A mutation in only one of the following genes ASXL1, SRSF2, EZH2, IDH1/2: Yes No N/A

At least 2 mutated genes among ASXL1, SRSF2, EZH2, IDH1/2: Yes No N/A

A mutation in only one of the following genes ASXL1, SRSF2, EZH2, IDH1/2, U2AF1Q157: Yes No N/A

At least 2 mutated genes among ASXL1, SRSF2, EZH2, IDH1/2, U2AF1Q157: Yes No N/A

ASXL1 mutated: Yes No N/A

Cytogenetics

Unfavourable by DIPSS plus ¹: Yes No N/A

Unfavourable by MIPSS70 plus v. 2.0²: Yes No N/A

Very high-risk by MIPSS70 plus v. 2.0³: Yes No N/A

¹= complex karyotype or sole or two abnormalities including +8, -7/7q-, i(17q), -5/5q-, 12p-, inv(3) or 11q23 rearrangement.
²= chromosomal abnormalities except “very high-risk” (see below) or "favorable" (sole 13q-, +9, 20q-, chromosome 1 translocation/ duplication or sex chromosome alterations including -Y)
³= single/multiple abnormalities of -7, i(17q), inv(3)/3q21,12p-/12p11.2,11q-/11q23,+21, or other autosomal trisomies except +8/9