Primary Myelofibrosis (PMF)

Prognostic Scores Calculator

Clinical Features

Age (y)

Gender

Male Female

Constitutional Symptoms

Yes No N/A

RBC transfusions need

Yes No N/A

Karnofsky <90%

Yes No N/A

HLA-mismatched unrelated donor

Yes No N/A

Complete Blood Count

Hb (g/dl)

WBC > 25x10⁹/l

Yes No N/A

Blasts (%)

PLT (x10⁹/l)

Driver Mutations Status

Absence of type 1/type 1 like CALR mutation

Yes No N/A

Non-CALR/MPL driver mutation genotype

Yes No N/A

Additional Myeloid Mutations

A mutation in only one of the following genes ASXL1, SRSF2, EZH2, IDH1/2

Yes No N/A

At least 2 mutated genes among ASXL1, SRSF2, EZH2, IDH1/2

Yes No N/A

A mutation in only one of the following genes ASXL1, SRSF2, EZH2, IDH1/2, U2AF1Q157

Yes No N/A

At least 2 mutated genes among ASXL1, SRSF2, EZH2, IDH1/2, U2AF1Q157

Yes No N/A

ASXL1 mutated

Yes No N/A

Cytogenetics

Unfavourable by DIPSS plus ¹

Yes No N/A

Unfavourable by MIPSS70 plus v. 2.0²

Yes No N/A

Very high-risk by MIPSS70 plus v. 2.0³

Yes No N/A

¹= complex karyotype or sole or two abnormalities including +8, -7/7q-, i(17q), -5/5q-, 12p-, inv(3) or 11q23 rearrangement.
²= chromosomal abnormalities except "very high-risk" (see below) or "favorable" (sole 13q-, +9, 20q-, chromosome 1 translocation/ duplication or sex chromosome alterations including -Y)
³= single/multiple abnormalities of -7, i(17q), inv(3)/3q21,12p-/12p11.2,11q-/11q23,+21, or other autosomal trisomies except +8/9

Risk Category (score)	Survival
DIPSS	-
DIPSS-Plus	-
MIPSS70	-
MIPSS70 plus version 2.0	-
MTSS	-